Final Four Picks: One Upset, One Chalk Will Cover the Vegas Odds

March Madness odds feature a couple of surprises on the second weekend of the NCAA Tournament, and now the field is set to make your Final Four picks. Here is a look at Saturday's Final Four games, to be held at Ford Field in Detroit.

Michigan State vs UConn odds – Saturday, April, 4, 6:07 PM ET

The No. 2 Spartans took the Midwest region with a 64-52 win over top-seeded Louisville, as they held the Cardinals to 38.3 percent from the field, while Goran Suton put up 19 points and 10 boards in the post. The No. 1 Huskies emerged from the West with an 82-75 win over a pesky Missouri team, as they got 23 points off the bench from freshman Kemba Walker (tying his career high). The Huskies outrebounded Mizzou 45-26.

UConn is the Final Four betting favorite in this contest with a four-point spread, and these two powerhouses split a pair of meetings in 1998 and 2000, with the home team winning each time. This is essentially a home game for the Spartans, as eight Michigan State players hail from Michigan, where the game will be played. Look for the crowd to spark Michigan State to a March Madness betting upset over the Huskies.

Villanova vs North Carolina odds – Saturday, April 4, 8:47 PM ET

The No. 3 Wildcats needed a last-second shot by Scottie Reynolds to upend top-seeded Pittsburgh in the East, and Villanova was money at the foul line, hitting 22 of it 23 attempts. No. 1 North Carolina had perhaps its best defensive performance of the season in a 72-60 win over No. 2 Oklahoma to take the South region. The Tar Heels harassed the Sooners into a 2-of-19 shooting day from three-point range, while keeping Blake Griffin relatively quiet.

The Tar Heels have a Final Four betting spread of 7.5 points and, even though they are 1-2 in three career games against the Wildcats, North Carolina beat 'Nova by 16 points in the Sweet 16 back in 2005. The Tar Heels have improved in each Tournament game and, if they play defense like they did against Oklahoma, there is no better team in the country. Bet on North Carolina to cover their Final Four odds.