NFL Handicapping: 49ers vs Colts

The San Francisco 49ers and the Indianapolis Colts will both be trying to pick up a win on Sunday when they battle at Lucas Oil Stadium. Oddsmakers currently have the Colts listed as 13½-point favorites versus the 49ers, while the game's total is sitting at 45. The 49ers lost to Houston 24-21 as a 3-point underdog in Week 7. The combined score went OVER the posted over/under total (44.5). Alex Smith passed for 206 yards with three touchdowns and an interception for San Francisco, while Vernon Davis caught seven passes for 93 yards and three touchdowns. The Colts defeated St. Louis 42-6 as a 14.5-point favorite in Week 7. The combined score went OVER the posted over/under total (45). Peyton Manning passed for 235 yards with three touchdowns for Indianapolis, while Reggie Wayne caught seven passes for 83 yards and a touchdown in the win. Current streak: San Francisco has lost 2 straight games. Indianapolis has won 6 straight games. Team records: San Francisco: 3-3 SU, 4-1-1 ATS Indianapolis: 6-0 SU, 5-1 ATS San Francisco most recently: When playing in November are 4-6 When playing on turf are 3-7 After being outgained are 6-4 When playing outside the division are 3-7 Indianapolis most recently: When playing in November are 8-2 When playing on turf are 9-1 After outgaining opponent are 9-1 When playing outside the division are 9-1 A few trends to consider: San Francisco is 4-1-1 ATS in its last 6 games on the road San Francisco is 4-1-1 ATS in its last 6 games San Francisco is 4-2 SU in its last 6 games when playing Indianapolis The total has gone UNDER in 4 of San Francisco's last 6 games on the road Indianapolis is 5-0 SU in its last 5 games Indianapolis is 5-0 ATS in its last 5 games Indianapolis is 5-0 SU in its last 5 games at home The total has gone OVER in 4 of Indianapolis's last 6 games when playing San Francisco Next up: San Francisco home to Tennessee, Sunday, November 8 Indianapolis home to Houston, Sunday, November 8