49ers vs Chargers NFL Odds

The San Francisco 49ers and the San Diego Chargers will both be trying to pick up a win on Friday when they battle at Qualcomm Stadium. Oddsmakers currently have the Chargers listed as 4-point favorites versus the 49ers, while the game's total has not yet been posted. The 49ers scored 17 points in the second half to come back and defeat the Cowboys 20-13 in Week 3 of the preseason as 6.5-point underdogs. The game's 33 points went UNDER the night's posted total of 38. The Chargers fell 27-24 to the Falcons in Week 3 of the preseason last time out as 3-point underdogs. The 51 points made it OVER the posted total of 42.5. Team records: San Francisco: 7-9 SU, 7-8-1 ATS San Diego: 8-8 SU, 7-8-1 ATS Next up: San Francisco at Arizona, Sunday, September 13 San Diego at Oakland, Monday, September 14